Mobility Front End
A mobility plug-in for mass spectrometers which enables a high speed, pre-filtration stage for liquid and gas samples. The Mobility Front End has been designed for users of MS in the search of greatest levels of selectivity*, especially in applications where a measure of the analyte diameter is required.
Upgrade your MS to tackle more and more challenging applications:
Polymer analysis, Food security and quality, Bio-based industries
Medicine And Biology
Metabolomics, Bio-molecules analysis, Serious illnesses diagnosis, Pharmacokynetics
Air/soil pollution, Geological studies
Drugs/explosives detection, Person identification (border checks), Industrial security (gas leakages)
Easy to plug in/out
DMA Front End is easy to operate. No specific preparation of samples is required. Besides, the Front End can be easily assembled and disassembled (plug in/out) from your mass spectrometer in only 5 minutes (the MS can be reused at any time as an stand-alone device). Once plugged-in, it operates in a fully-integrated approach through easy-to-use software (For ABSciex MS, operation will proceed through the software already built-in in your MS).
- High resolution (up to 50)
- High versatility: the Front End can be disassembled at any time and leave the MS as a stand alone.
- Plug in/out to/from your MS in 5 minutes.
- Lowest limits of detection available (1ppq for TNT)
- Compelling advantages for the analysis of polymers and bio-molecules
- Reduced sampling time due to higher sensitivity.
- Accomplishment of measurements in real time (seconds to minutes depending on the application).
- Complex samples can be thoroughly analyzed (including discovery mode) through a 2D mass-mobility analysis.
- Robust, highly engineered construction, featuring mirror polishing, micro-slots and full thermal control for the maximum standard of reliability.
- Analytes are ionized in the gas-phase through various pathways:
- Charge exchange
- Proton transfer/deprotonation
- Electron capture
- Charged adduction
- APPI works in both positive and negative modes
- Applicable to both polar and non-polar compounds (most universal source for LC-MS)
- Broad linear dynamic range
- Minimal susceptibility to matrix effects
Motivation and objectives
The project motivation is develop an ion source for the analysis of vapour samples containing non-polar analytes using DMA-MS technologies.
The main objetives are:
- Develop a prototype APPI-DMA-MS source
- Characterize device performance
- Identify key applications
- Refine source design: produce a 2nd prototype (Version 2.0), suitable for commercial use
Key SEADM Technologies
Differential Mobility Analyzer (DMA)
- Integrates with MS to add an ion mobility element
- Intended to reduce need for LC equipments
- Minimizes sample throughput time
- Provide high sensitivity and resolution
- Secondary electrospray ionization (SESI)
- Intended for the analysis of vapours
- Based upon a nanospray; gas-phase analyte ionization
- Also APCI; performance limited for non-polars
The most important reasons to use Atmospheric Pressure Photoionization are:
- ESI/SESI suitable for polars, not ideal for non-polars
- Applied typically to LC-MS methods; good for non-polar analysis
- Gas-phase chemical ionization method; adapts well to vapour analysis
- Dopant (D) generally used to enhance analyte (M) ionization efficiency
APPI-DMA Prototype Version 1.0
There are two possible configurations: